The added value of umbilical vein flow in predicting fetal macrosomia at 36 weeks of gestation: A prospective cohort study

Introduction Current models based on fetal biometry and maternal characteristics have a poor performance in predicting macrosomia. The primary aim of this study was to elucidate the diagnostic venous arterial Dopplers macrosomia third trimester pregnancy; secondary build multiparametric prediction model including pregnancy, ultrasound Doppler able predict accurately. Material methods Prospective cohort 2156 singleton pregnancies scheduled for routine assessment at 36 weeks gestation. Fetal biometry, estimated weight (EFW), pulsatility index uterine, umbilical, middle cerebral arteries, cerebroplacental ratio umbilical vein blood flow (UVBF) normalized abdominal circumference (UVBF/AC) were recorded. Primary outcome macrosomia, defined as birthweight >90th percentile; newborns >4000 g. Logistic regression area under curve (AUC) analyses used analyze data. Results complicated 9.8% pregnancies, 7.7% had At multivariate logistic analysis, body mass (adjusted odds [aOR] 1.23), pregestational diabetes (aOR 1.83), prior newborn with >95th centile 1.49), EFW 2.23) UVBF (aOR1.84) independently associated whereas gestational mellitus (P = .07) or any other parameters not. an AUC 0.750 0.801 alone association respectively. addition significantly improved provided by 0.892 (De Long P .044 .0078, respectively). predictive g similar when included algorithm. Conclusions Umbilical evaluation improves diagnosis optimal is achieved flow, EFW.